The AHPBA was formed in 1998 as an association within the Gastroenterological Society of Australia (GESA). The intention was to create a multi-disciplinary group to further the practice of HPB medicine and surgery. Successful activities of the AHPBA included organising several meetings, usually in association with the Australian Gastroenterology Week (AGW), and facilitating an overseas fellowship (The Paul MacMaster Fellowship). The group also had dialogue with government through participation in MSAC committees.
In April 2005, the Association was reformed outside the GESA. The Australian New Zealand Hepatic, Pancreatic and Biliary Association Inc was registered in early 2006. The Secretariat is currently based in Adelaide.